Cover: T-tropic AAV
A butterfly, symbolizing systemic lupus erythematosus (SLE), is caught in a net woven from T-shaped links. Antibody patterns on its wings evoke the pathogenic autoantibodies characteristic of SLE, while the T-shaped net represents engineered T cells deployed to capture the disease. This image illustrates how a human T-cell-targeted AAV vector generates CAR-T cells in vivo to deplete B cells and ameliorate lupus pathology.
See Lu, Z. et al., P125–139